I pulled out an older game from my collection to play this past weekend.
Star Trek: Fleet Captains really gives a nice feel to the show with a variety of missions from combat, influence, and science. It has it's faults, but we had a good time.
For those that have played it, what do you think of the expansions. I only have the base game, but am very tempted to get the Romulan and Dominion expansions.